This page, although not directly stating it, eloquently displays the fact that S. was the man that killed Agent #4. As explained, a bearded traveller had passed the poison filled bottle, which was later thrown to the bottom of a river, and then got off the train well before the dead body was found. Furthermore, this bearded man, S., is stated to be secretly paddling away along the river. This initial murder makes it clear that S. is on a mission.
Within the margins Jen tells Eric that her coworker had seen Moody stumbling into the cafe later the night before. It is clear that Moody is struggling. Furthermore, they continue to discuss the rakija that Eric once drank.