“The RIO kinases: Structure, Function and Inhibition”
Please join us in welcoming the Anderson Freemen Guest Lecturer, Dr. Nicole LaRonde, Associate Professor of Chemistry and Biochemistry at the University of Maryland.
Dr. LaRonde’s laboratory is focused on the study of molecules required for the synthesis of new ribosomes. A proliferating cell devotes 75% of its energy towards making these machines for protein synthesis. In the process of assembly of this large complex of RNA and proteins, an estimated 400 ribosome processing factors are utilized in humans. Although many of these proteins and protein-RNA complexes have been identified, for several of them their exact function in the process remains unknown. They are interested in determining the molecular details of how these macromolecules function in eukaryotic organisms.
The lab is currently studying the structural biology of the RIO kinases, a group of ancient atypical serine protein kinases, and Nep1, a putative RNA methyl transferase. These molecules are essential for the processing of the small ribosomal, or 40S, subunit. The role of these molecules in the synthesis of ribosomes is still unclear, but armed with X-ray crystal structures we are probing the interactions between these molecules and the rRNA, as well as with other molecules involved in the process. Our work thus far has elucidated how the RIO kinases interact with ATP and the pre-mature small subunit of the ribosome, and how Nep1 interacts with RNA. Our current work involved using these structures to guide questions in biochemical and biological contexts.
Friday, November 10 at 1:45 pm in BiHall 216
The Marcus Autism Center, in conjunction with the Emory University School of Medicine and Children’s Healthcare of Atlanta, is offering three fellowships:
- Cohen Fellowship in Developmental Social Neuroscience
- Marcus Fellowship in Speech Science and Engineering
- Simons Fellowship in Computational Neuroscience
Research fellowships are intended for college graduates to dedicate two intensive years to research on ASD prior to entering graduate studies. Fellows will participate in and guide innovative research while working with families and children affected by ASD, ranging in age from week-old infants to adolescents and young adults.
Fellows receive direct research mentorship from the program directors and Marcus Autism Center faculty members, and they are involved in a highly active and productive community of
clinical research scientists. In addition to research training and mentorship, fellows also complete an intensive summer training seminar covering clinical research in ASD (one week), ASD grand rounds meetings (twice a month), social neuroscience lab meetings (weekly) and ongoing didactic practica. Fellows are strongly encouraged and expected to submit their research for posters and publications and will be funded to attend at least one conference a year.
All three fellowship tracks are paid, two-year positions, with full healthcare coverage.
Visit marcus.org/fellowship for more information and to download an application.
Biomedical research is the broad area of science that looks for ways to prevent and treat diseases that cause illness and death in people and in animals. This general field of research includes many areas of both the life and physical sciences. Utilizing biotechnology techniques, biomedical researchers study biological processes and diseases with the ultimate goal of developing effective treatments and cures. Biomedical research is an evolutionary process requiring careful experimentation by many scientists, including biologists and chemists. Discovery of new medicines and therapies requires careful scientific experimentation, development, and evaluation. -New Jersey Association for Biomedical Research
If you want to see if biomedical research is a possible career path for you, our friends at the Fred Hutchinson Cancer Research Center have shared a resource they developed, which is a catalog of biomedical research internships offered nationwide for high school, undergraduate, post-baccalaureate, graduate, and first-year medical students. You can check it out online here.
The Fred Hutchinson Cancer Research Center (Fred Hutch) hosts a summer internship that is designed to provide biomedical research experience and mentorship for undergraduate students of rising senior status.
About the Summer Undergraduate Research Program (SURP)
The SURP is an intensive, 9-week internship designed to provide research experience and mentorship for rising-senior undergraduate students who are interested in biomedical research. Under the guidance of a faculty mentor, students will:
- Complete an independent research project;
- Attend weekly research seminars;
- Participate in professional development workshops designed to facilitate the preparation of competitive applications for graduate/medical school; and
- Present their findings at a competitive poster session.
The program will run from Monday, June 11 – Friday, August 10, 2018.
An online application for the 2018 SURP will be available via the SURP website in mid-November 2017.
The application deadline is midnight Pacific Standard Time (PST) on Friday, January 12, 2018.
Letters of recommendation for up to two references are due by midnight Pacific Standard Time (PST) on Friday, January 19, 2018.
The Office of Science / US Department of Energy is pleased to announce paid research internship opportunities for undergraduate students majoring in areas of Science, Technology, Engineering, and Mathematics (STEM). The application system for the Term Science Undergraduate Laboratory Internships (SULI) program is currently open, with all applications due by 05:00 PM Eastern Time on January 12, 2018.
The Science Undergraduate Laboratory Internships (SULI) program places students from 2 and 4 year undergraduate institutions as paid interns in science and engineering research activities at DOE national laboratories and facilities, working with laboratory staff scientists and engineers on projects related to ongoing research programs. Appointments are for 10 weeks during the Summer term, are open to US Citizens and US Lawful Permanent Residents, include a weekly stipend, reimbursement for one round trip domestic travel to the participant’s host DOE laboratory, and possibilities for a housing allowance. More than 850 internships are sponsored annually.
Application is made online. Full program information and descriptions, including links to the online application system, are available here.