Tag Archives: Clinical Research

Research Associate for the Clinical Genome Resource at the Broad Institute of MIT and Harvard

Thanks to Andrew Grant ’17 for sharing this opportunity with us!

The Clinical Genome Resource at the Broad Institute of MIT and Harvard is seeking a motivated individual to work in a cutting-edge environment to serve as a research associate for the Clinical Genome Resource (ClinGen). ClinGen is an NIH-funded program that is building authoritative resources to define the clinical relevance of genes and variants for use in precision medicine and research (www.clinicalgenome.org). This position would begin with training within our variant and gene-curation team which supports variant classification and gene-disease validity assessment followed by supporting an array of ClinGen disease-specific Expert Panel activities and affiliated projects within ClinGen and at the Broad Institute.

PRINCIPAL DUTIES AND RESPONSIBILITIES

  1. Support ClinGen curation activities
    1. Research the significance of variants and genes through literature and data review
    2. Classify variant- and gene-disease associations
    3. Support research projects that require curation of genomic knowledge
  2. Support the ClinGen’s mission to provide better access to genomic data
    1. Support the sharing of curated knowledge with the community
    2. Assist laboratories with data submission to ClinVar (www.ncbi.nlm.nih.gov/clinvar)
    3. Collect data from locus-specific databases to deposit into ClinVar
    4. Assist in the development of software tools for supporting variant and gene curation
    5. Assist in resolving variant interpretation differences between ClinVar submitters
    6. Assist Clinical Domain WGs in supporting gene and variant curation programs
    7. Support the writing of ClinGen research publications
  3. Support other projects related to genetic and genomic testing and research at the Broad

In addition, the Research Associate should possess excellent organizational skills and the ability to interact effectively with a local team at the Broad Institute and an international network of laboratories and data sources and balance and manage multiple tasks and projects independently. We request a minimum of a two-year commitment.

Start date: May or June 2019

Qualifications: BA or BS degree in the sciences

Job location: The Broad Institute of MIT and Harvard, 105 Broadway, Cambridge, MA

Reports to: Heidi Rehm, PhD, Principal Investigator, Clinical Genome Resource

 For more information, please contact Heidi Rehm, PhD (hrehm@broadinstitute.org)

Two Research Associate Positions Open in Pediatric Oncology at Dana Farber

There are two RA positions open in Pediatric Oncology at Dana Farber. Dr. Birgit Knoechel writes, “The overarching goal of my lab and the Lohr lab is to study the biology of therapeutic resistance in cancer with a particular focus on genomic and epigenetic aberrations. We use single cell/low input genomics, epigenomics and other single cell technology to define dynamic changes in tumor model systems and primary patient samples with a disease focus on hematologic malignancies and sarcoma. We also use a wide variety of tools to study underlying mechanisms, which span the entire spectrum from biochemistry, functional perturbation to in vivo mouse models.”

Click on the titles to learn how to apply.

RA Epigenetics – The Dana-Farber Cancer Institute is looking for an exceptional candidate for a unique Research Associate position. This position affords the exciting opportunity to be part of a research effort at Dana-Farber Cancer Institute aiming to delineate epigenomic aberrations in cancer and discover novel therapeutic targets. The candidate will assist in the development of cancer models from primary human tumors and human cell lines that represent different cellular lineages and drug-resistant states. He/she will use modern next generation sequencing techniques to characterize the chromatin state of these tumors and modern functional perturbation techniques including lentiviral knockdown and CRISPR/Cas9 genome editing tools. He/she will test the model systems in immuno-compromised mice for their ability to form tumors and to test for drug responses. He/she will be part of a multi-disciplinary team that evaluates new technologies and approaches to discover and validate novel systemic cancer biology.

RA Genomics – Dana-Farber Cancer Institute is looking for an exceptional candidate for a unique Research Associate position. This position affords the exciting opportunity to be part of a research effort at Dana-Farber Cancer Institute aiming to delineate genomic aberrations in cancer biology and discover novel therapeutic targets. He/she will use modern next generation sequencing techniques to characterize genomic aberrations and modern functional perturbation techniques including CRISPR/Cas9 and other genome editing tools. He/she will use various model systems to test for drug responses and determine mechanisms of resistance to drugs, including novel immunotherapies. He/she will be part of a multi-disciplinary team that evaluates new technologies and approaches to discover and validate novel systemic cancer biology.

Clinical Research Coordinator – Multiple Meyloma at Dana-Farber

This position is brought to you by Annie Cowan ’18 – application deadline February 3rd:

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, they provide compassionate and comprehensive care to patients of all ages; they conduct research that advances treatment; they educate tomorrow’s physician/researchers; they reach out to underserved members of their community; and they work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The Clinical Research Coordinator works within the clinical research program and supports the research team in the overall conduct of clinical trials using Good Clinical Practice under the auspices of the Principal Investigator(s) and the DFCI Clinical Trials Office. The CRC will be responsible for the primary data collection and management of patient clinical information as it pertains to participation in clinical trials. Ensures timely collection of protocol related samples including shipment to outside entities as required. Maintains regulatory binders and ensures study compliance with all state, federal, and IRB requirements. May be responsible for IRB protocol submissions (amendments, continuing reviews, and minimal risk protocols). This individual may also screen patients for protocol eligibility, obtain informed consent, and register study participants to clinical trials. Some travel may be required

Learn more in Handshake.

THANC Foundation Research Associate

Brought to you by Midd Alum Kayvon Sharif ‘16.5.

The THANC (Thyroid, Head and Neck Cancer) Foundation is a non-profit organization committed to supporting research and education in the early detection and treatment of thyroid and head and neck cancer, to advancing new therapies, and to alleviating the suffering and functional impairment of patients who undergo treatment.

Role: Research Associates collaborate with an interdisciplinary group of physicians and researchers affiliated with Mount Sinai Downtown Medical Center to conduct and publish clinical research. In addition, Research Associates also play key roles in the development and maintenance of a disease-specific electronic medical record system and an educational website for patients and their families (www.headandneckcancerguide.org). Finally, Research Associates have the opportunity to spend time observing thyroid and head and neck surgery in the operating room.

Qualifications/Required Documents: This is a full-time, two-year position. Research Associates must hold a Bachelor’s degree and typically have a strong interest in pursuing a career in medicine. Applicants should have a robust scientific background, excellent writing ability, and previous experience in a clinical environment is desired as well.

To apply:

  • Provide a cover letter (addressed to Dr. Urken), an updated CV, and two letters of recommendation to ksharif@thancfoundation.org.
  • Please have your recommenders e-mail your letters directly.
  • If selected for an interview, a writing assignment will be required.
  • The application deadline is February 1, 2019 but we are gladly accepting applications before then.

For more information, please visit our website (www.thancfoundation.org), or feel free to contact Kayvon Sharif directly with any questions you may have!

Research Assistant Positions at Brigham and Women’s

There are TWO positions open at the Orthopedic and Arthritis Center for Outcomes Research at Brigham and Women’s Hospital, Harvard Medical School. Start dates for the positions are June, 2019. These are great positions for students considering careers in medicine, public health, public policy, economic evaluation and related fields.

We are seeking to hire a full-time Research Assistant to work with our internationally recognized, multidisciplinary health policy and clinical outcomes research team at the Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) and the Policy and Innovation eValuation in Orthopaedic Treatments (PIVOT) Centers, both in the Department of Orthopedic Surgery at Brigham and Women’s Hospital and Harvard Medical School. The incumbent will be essential to the research operations of OrACORe/PIVOT and will be an integral member of the centers.

The Research Assistant will work directly with the Principal Investigators of the centers, as well as numerous other faculty and staff members, to conduct clinical research involving musculoskeletal conditions. There will be opportunities to collect data, synthesize literature, and write both manuscripts and sections of grant proposals. The Research Assistant will also participate in conducting health policy evaluations of musculoskeletal diseases using computer simulation modeling

  1. Health Policy and Clinical Research Assistant at Brigham and Women’s Hospital, Department of Orthopedic Surgery – Read the full job description here.
  2. Clinical and Health Policy Research Assistant at Brigham and Women’s Hospital, Department of Orthopedic Surgery – Read the full job description here.

 

Research assistant openings in the Zon Lab, Boston/Cambridge MA

Work as a Research Assistant with Dr. Leonard Zon, Grousbeck Professor of Pediatrics at Harvard Medical School, HHMI Investigator, and HSCI Faculty Member.

The lab utilizes the zebrafish model system and cutting-edge technologies to study the role of gene expression in hematopoiesis, cancer, and stem cell development. They aspire to develop and improve drug therapies and treatments for patients with blood disorders and cancer. The lab is based in two locations: Longwood Medical Area (Boston) and Harvard University (Cambridge).

They carry out research in two areas of biology:

  • Hematopoiesis: Each day, humans require the production of ~100 billion new blood cells for proper hematopoietic function. Assaults to this system can cause diseases including leukemias, lymphomas, and anemias. They study how hematopoietic progenitor cells are induced from vascular precursors, how hematopoietic stem cells (HSCs) engraft
    into their stem cell niche, what genes controls stem cell self-renewal and differentiation, what goes awry in blood cancers & diseases, and how to improve treatments such as bone marrow transplants.
  • Melanoma: The Zon Lab created the first animal model of a BRAFdriven cancer in 2005 with the publication of our zebrafish melanoma model. The lab has gone on to identify genes important in melanoma initiation such as SPRED1 and SETDB1. They study epigenetic regulators of melanoma onset, molecular events in melanoma initiation, and mechanisms of melanoma drug resistance

Positions available:

  • Research Assistants: They are looking for multiple candidates with strong biology backgrounds. Research assistants will utilize a variety of molecular biology techniques, microinjections, microscopy, and tissue culture in addition to working with zebrafish.
  • Bioinformatics Specialist: The last three bioinformatics specialists in their lab have been premedical students with a computer science focus. The individual will work on widely applicable computational analyses on the data from lab experiments and will learn to create novel analysis pipelines to handle more complex biological questions.

Qualities they are looking for: Highly motivated, intellectually curious, strong organizational skills, and an ability to work independently.

Benefits to you: Many recent college graduates spend time as Zon Lab research assistants prior to successfully moving on to positions in medical school, graduate school and other health professions. You will learn how to design and execute state-of-the-art experiments, providing an excellent opportunity to grow creatively as a scientist and to think critically about how the lab translates to the clinic. Research assistants regularly give presentations and are authors on primary research papers, providing a competitive edge when applying to graduate and medical programs.

Email your cover letter & CV to Dr. Bruce Barut (Lab Manager).
Positions are competitive and require a two-year commitment beginning summer 2019

Research Coordinator Positions Open in the Stress and Development Lab at Harvard

An experienced, independent, and highly-organized individual is sought for a full-time Research Coordinator position in the Stress and Development Laboratory at Harvard University Psychology Department, run by Katie McLaughlin, PhD.  The position will begin in summer 2019 (ideally June).  Research examines the impact of environmental experience on children’s development. Most of their studies are focused on identifying developmental mechanisms linking adverse environmental experiences to the onset of psychopathology.

Under the supervision of Dr. McLaughlin, the individual in this position will be involved in managing an active research lab with several large grants and participate in many aspects of the research process, including recruitment of children and adolescents into research, preparation of IRB applications, data collection, supervision of volunteer research assistants, data management, programming behavioral tasks, and development and maintenance of a database for participant recruitment and tracking.  These duties will primarily focus on an intensive repeated-measures fMRI study examining dynamic changes in neural networks following exposure to stress in adolescents.  Data collection for these studies involves acquisition of psychophysiology and MRI data in addition to assessments of mental health and exposure to stress and adversity.

Duties and Responsibilities:

  • Collect data from children, adolescents, and parents in multi-modal studies involving psychophysiology, neuroimaging, and mental health assessments
  • Supervise a team of research assistants in data collection and data management
  • Prepare IRB applications
  • Program behavioral tasks
  • Clean and organize data for analysis
  • Develop and maintain databases for participant recruitment and tracking

Qualifications:

  • Bachelor’s degree in a relevant academic area
  • Experience working with children and adolescents
  • Experience with task presentation software (e.g., Eprime, Psychopy, MATLAB) is preferred
  • Experience in analyzing neuroimgaging data (i.e., MRI, fMRI, DTI) and comfort working in a command-line environment (e.g., Linux) is preferred

Please contact lab managers, Steven Kasparek and Azure Reid-Russell, for details on how to apply: sdlab@fas.harvard.edu