Please join the Biology Department for their next Biology Seminar: “Troubles in Mitosis: mechanisms to preserve the integrity of the genome.”
Friday, October 25, 2013 @ 12:30 pm, MBH 220
Lecture by Dr. Greenfield (Kip) Sluder, Midd ’68, Department of Cell and Developmental Biology, University of Massachusetts Medical School
The purpose of mitosis is to generate genetically identical daughter cells. Aberrant chromosome segregation can predispose cells to cancerous transformation. The mitotic checkpoint is a quality control mechanism that deals with naturally occurring problems in chromosome attachment to the spindle. However, some intractable spindle defects eventually allow checkpoint satisfaction and completion of defective mitosis. For normal human cells we find that modest prolongations of
mitosis lead to a durable cell cycle arrest due to the partial, but not lethal, activation of the programmed cell death pathway. This could serve to handle problems, such as short/multipolar spindles induced by environmental toxins, which are not caught by the mitotic checkpoint.