March 13, 2015
by Nicole Veilleux
We seek a highly motivated and organized individual to join our efforts to develop novel therapies for treatment‐resistant leukemias of childhood. Our approach combines functional genetics, biochemistry and drug screens in the zebrafish model system, in mouse models, and in human cancer cells. The selected candidate will work directly on experimental research projects (85% effort), and will also spend 15% effort on lab management duties including maintenance of zebrafish or mouse lines, purchase ordering, and preparation of general lab supplies such as bacterial plates and stock solutions. A highly motivated and productive technician may get the opportunity to lead an independent research project within the lab.
A bachelor’s degree is required, preferably with formal study in molecular biology, genetics, biochemistry or chemistry. The candidate must be a responsible individual with strong communication, organizational and interpersonal skills. Previous experience in scientific research would be an asset. Experience with zebrafish or mouse research is not required, but enthusiasm for learning modern molecular oncology techniques is essential, including cell culture, microinjection of zebrafish embryos, phenotypic screening, and tumor cell sorting/analysis.
40 hour/week full‐time position with flexible hours and competitive salary/fringe benefits. Anticipated start date is May or June 2014. A 2‐year minimum commitment is required. A great transition opportunity for a graduating undergraduate student interested in pursuing a graduate or medical education after 2 years. Most previous Gutierrez technicians have been co‐authors on several papers and are now in medical school.
1. Gutierrez A, et al. (2009) Blood, 114:647-50.*
2. Gutierrez A, et al. (2010) Journal of Clinical Oncology, 28:3816-23.*
3. Gutierrez A, et al. (2010) Blood, 115:2845-51.*
4. Gutierrez A, et al. (2011) Journal of Experimental Medicine, 208:1595-603.*
5. Gutierrez A, et al. (2011) Blood, 118:4169-73.*
6. Inuzuka H, et al. (2011) Nature, 471 :104-9.
7. Gutierrez A, et al. (2011) Proc Natl Acad Sci U S A, 108:16386-91.*
8. Sanda T, et al. (2013) Cancer Discovery, 3:564-77.
9. Mansour MR, et al. (2013) Journal of Experimental Medicine, 210:1545-57.
10. Ni Chonghaile T, et al. (2014) Cancer Discovery, 4 :1074.
11. Gutierrez A, et al. (2014) British Journal of Haematology, .*
12. Knoechel B, et al. (2014) Nature Genetics, 46:364.
13. Gutierrez A, et al. (2014) Journal of Clinical Investigation, 124:644.*
14. Reynolds C, et al. (2014) Leukemia, 28 :1819.*
15. Mansour M, et al. (2014) Science, 346 :1373.
*Papers on which Gutierrez technicians have been co‐authors
Please send inquiries and resume to principal investigator. College transcripts and 3 letters of
reference will be needed upon request.
Job Function: Research technician and laboratory manager.
Additional Details: Boston Children’s Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of Harvard Medical School.
Lab Website: http://theaglab.com
Application Method: Please apply by email to laboratory principal investigator: Alejandro Gutierrez, MD